Impaired presynaptic inhibition in the motor cortex in Parkinson disease
Identifieur interne : 002094 ( Main/Exploration ); précédent : 002093; suivant : 002095Impaired presynaptic inhibition in the motor cortex in Parkinson disease
Auteurs : J. Chu [Canada] ; A. Wagle-Shukla [Canada] ; C. Gunraj [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Source :
- Neurology [ 0028-3878 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABAA receptors, and long interval intracortical inhibition (LICI), likely mediated by GABAB receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABAB mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired. Methods: Eleven patients with PD were studied at rest both OFF and ON dopaminergic medications and the results were compared to nine healthy, age-matched controls. Motor evoked potentials were recorded from the first dorsal interosseous muscle and a triple-stimulus transcranial magnetic stimulation paradigm was used to evaluate SICI in the presence of LICI. The interstimulus interval (ISI) for SICI was 2 msec and LICI was studied at 100 (LICI100) and 150 msec (LlCl150)ISIs. Results: There was no difference in SICI between the controls and PD ON and PD OFF groups. LICI100 was stronger than LICI150 and both were reduced in the PD ON and OFF groups. LICI100 led to a much greater reduction in SICI in the control group compared to both the PD OFF and ON groups. LICI150 caused no significant change in SICI with no significant difference between the controls and PD OFF and PD ON groups. Conclusions: The inhibitory effect of long interval intracortical inhibition on short interval intracortical inhibition, likely representing presynpatic inhibition in the motor cortex, is decreased in Parkinson disease and may be a nondopaminergic feature of the disease.
Affiliations:
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Wagle-Shukla</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C." last="Gunraj">C. Gunraj</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R." last="Chen">R. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0141313</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0141313 INIST</idno><idno type="RBID">Pascal:09-0141313</idno><idno type="wicri:Area/PascalFrancis/Corpus">000562</idno><idno type="wicri:Area/PascalFrancis/Curation">000730</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000457</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000457</idno><idno type="wicri:doubleKey">0028-3878:2009:Chu J:impaired:presynaptic:inhibition</idno><idno type="wicri:Area/Main/Merge">002261</idno><idno type="wicri:Area/Main/Curation">002094</idno><idno type="wicri:Area/Main/Exploration">002094</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impaired presynaptic inhibition in the motor cortex in Parkinson disease</title><author><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J." last="Chu">J. Chu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A." last="Wagle-Shukla">A. Wagle-Shukla</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C." last="Gunraj">C. Gunraj</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R." last="Chen">R. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Motor cortex</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Presynaptic inhibition</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Inhibition présynaptique</term><term>Cortex moteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA<sub>A</sub> receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA<sub>B</sub> receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA<sub>B</sub> mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired. Methods: Eleven patients with PD were studied at rest both OFF and ON dopaminergic medications and the results were compared to nine healthy, age-matched controls. Motor evoked potentials were recorded from the first dorsal interosseous muscle and a triple-stimulus transcranial magnetic stimulation paradigm was used to evaluate SICI in the presence of LICI. The interstimulus interval (ISI) for SICI was 2 msec and LICI was studied at 100 (LICI<sub>100</sub>) and 150 msec (LlCl<sub>150</sub>)ISIs. Results: There was no difference in SICI between the controls and PD ON and PD OFF groups. LICI<sub>100</sub> was stronger than LICI<sub>150</sub> and both were reduced in the PD ON and OFF groups. LICI<sub>100</sub> led to a much greater reduction in SICI in the control group compared to both the PD OFF and ON groups. LICI<sub>150</sub> caused no significant change in SICI with no significant difference between the controls and PD OFF and PD ON groups. Conclusions: The inhibitory effect of long interval intracortical inhibition on short interval intracortical inhibition, likely representing presynpatic inhibition in the motor cortex, is decreased in Parkinson disease and may be a nondopaminergic feature of the disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J." last="Chu">J. Chu</name></noRegion><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R." last="Chen">R. Chen</name><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C." last="Gunraj">C. Gunraj</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A." last="Wagle-Shukla">A. Wagle-Shukla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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